Title: Physeo Anki Decks / 04 - Biochemistry / 04 - Genetics / Section 09.1 - Huntington Disease

Q: Huntington disease is associated with low levels of [neutrotransmitter]
A: Acetylcholine
Extra: Seagulls on the ground = Low acetylcholine

Q: Patients with Huntington disease experience [...], characterized by twisting and contorsion of the fingers
A: athetosis
Extra: Strangely shaped tree = Athetosis

Q: Huntingtons diseases shows a tendency to occur earlier or to be more severe in succeeding generations, which is known as [genetic term]
A: anticipation
Extra: Hunting family members getting progressively younger = Anticipation

Q: Patients with Huntington disease experience [...], characterized by [...] without purpose
A: chorea; sudden, jerky movements
Extra: Wacky, wavy, inflatable tube man = Chorea

Q: [...] is characterized as a trinucleotide repeat disorder due to build up of the repeated sequence [...] in DNA
A: Huntington Disease; CAG
Extra: Cage spelled "CAG" = repeated sequences of CAG

Q: Huntington disease is associated with low levels of [inhibitor neutrotransmitter]
A: GABA
Extra: Gabe falling down = Low GABA

Q: In Huntingtons disease the [receptor] is bound (overactive) causing excitotoxicity and eventual cell dealth
A: NMDA receptor
Extra: Teenager hugging the "No More Drugs or Alcohol" sign = NMDA binding
**Atropy of caudate and putamen**

Q: Huntington disease is follows a(n) [...] inheritance pattern
A: autosomal dominant
Extra: Teenagers playing with dominoes = Autosomal dominant

Q: Patients with Huntington disease often experience [...] and aggression
A: depression
Extra: Sad, whimpering golfer = Depression

Q: Patients with Huntington disease often experience depression and [...]
A: aggression
Extra: Angry golfer = Agression

Q: Huntingtons disease is associated with atropy of the [...] and putamen in the brain
A: caudate
Extra: Shooting cod fish = Caudate atrophy

Q: Huntingtons disease is associated with atropy of the caudate and [...] in the brain
A: putamen
Extra: Shooting the putting green = Putamen atrophy

Q: Huntington disease is associated with high levels of [neutrotransmitter]
A: dopamine
Extra: Teenager high on dope = High dopamine

Q: Huntington disease occurs due to build up of CAG repeats in the [gene] on chromosome 4
A: HTT gene
Extra: Ball getting hit with the golf club = HTT gene

Q: Huntington disease occurs due to build up of CAG repeats in the HTT gene on [chromosome]
A: chromosome 4
Extra: Man yelling "FORE" = Chromosome 4