Title: Physeo Anki Decks / 04 - Biochemistry / 04 - Genetics / Section 10.1 - Down Syndrome

Q: Down syndrome present with [increased or decreased] estrogen
A: decreased
Extra: Fallen "E" street sign = Low estrogen

Q: Down syndrome present with [increased or decreased] maternal serum alpha-fetoprotein (MSAFP)
A: decreased
Extra: Sap dripping down from the "M" etched into the tree = Low materal serum alpha-fetoprotein

Q: Down syndrome presents with [increased or decreased] β-hCG
A: increased
Extra: Burglar stealing HDTV out the upper window = Increased ß-hCG

Q: Down syndrome presents with [increased or decreased] inhibin A
A: increased
Extra: Girl with "A" on her shirt being abducted onto the roof = elevated inhbiin A

Q: Patients with Down Syndrome have an increased risk of developing [which leukemia] and acute lymphoblastic leukemia (ALL)
A: acute myelogenous leukemia (AML)
Extra: Mile markers along bloody river = Acute myelogenenous leukemia

Q: Patients with Down Syndrome have an increased risk of developing acute myelogenous leukemia (AML) and [which leukemia]
A: acute lymphoblastic leukemia (ALL)
Extra: Bandit blasting round, white rocket = Lymphoblastic leukemia

Q: Down syndrome is usually occurs due to [...], which increases with increased maternal age
A: nondisjuction
Extra: Conjoined twins = Nondisjunction

Q: Down syndrome is usually occurs due to nondisjuction, which increases with [increased or decreased] maternal age
A: increased
Extra: Old woman holding infant = Increases with increased materal age

Q: Clinical manifestations of Down syndrome include:
1.) Single [...]
2.) Brushfield spots
3.) Epicanthal folds
4.) Increased space between 1st two digits
A: palmar crease
Extra: Victim holding up hold exposing crease = Single palmar crease

Q: Clinical manifestations of Down syndrome include:
1.) Single palmar crease
2.) [spots]
3.) Epicanthal folds
4.) Increased space between 1st two digits
A: Brushfield spots
Extra: Bandits spotted by helicopter = Bushfield spots

Q: Clinical manifestations of Down syndrome include:
1.) Single palmar crease
2.) Brushfield spots
3.) [folds]
4.) Increased space between 1st two digits
A: Epicanthal folds
Extra: Fallen can smashing against the ground = Epicanthal folds

Q: Clinical manifestations of Down syndrome include:
1.) Single palmar crease
2.) Brushfield spots
3.) Epicanthal folds
4.) Increased space between [which digits]
A: 1st two digits
Extra: Dog biting bandit between 1st and 2nd toe = Increased space between first two digits

Q: Down syndrome is associated with [...] on fetal ultrasound
A: nuchal translucency
Extra: Mother dog carrying her pup by the nap of the neck = Nuchal translucency

Q: Down syndrome is often associated with:
1.) [intestinal defect]
2.) Early-onset Alzheimer disease
3.) Duodenal atresia
4.) Atrioventricular cardiac defects
A: Hirschsprung disease
Extra: Hershey's candy bar = Hirschsprung disease

Q: Down syndrome is often associated with:
1.) Hirschsprung disease
2.) Early-onset [...]
3.) Duodenal atresia
4.) Atrioventricular cardiac defects
A: Alzheimer's dementia
Extra: Old man yelling at his candy bar = Alzheimer's dementia

Q: Down syndrome is often associated with:
1.) Hirschsprung disease
2.) Early-onset Alzheimer's dementia
3.) [atresia]
4.) Atrioventricular cardiac defects
A: Duodenal atresia
Extra: Bandit smashing double barrel shotgun against rock = Duodenal atresia

Q: Down syndrome is often associated with:
1.) Hirschsprung disease
2.) Early-onset Alzheimer's dementia
3.) Duodenal atresia
4.) [...] cardiac defects
A: Atrioventricular
Extra: ATV smoking and malfunctioning = Atrioventricular cardiac defects