Title: Physeo Anki Decks / 04 - Biochemistry / 05 - Metabolism / Section 19.3 - Metachromatic Leukodystrophy

Q: Metachromatic Leukodystrophy is a [type is disease]
A: lysosomal storage disease
Extra: Lizard = Lysosomal storage disease

Q: [lysosomal storage disease] is caused by a deficiency in [enzyme]
A: Metachromatic leukodystrophy; arylsulfatase A
Extra: Ariela the mermaid is paralyzed by magic = Arylsulfatase A is the deficient enzyme

Q: In [lysosomal storage disease] the accumulated substrate is [...]
A: Metachromatic leukodystrophy; cerebroside sulfate
Extra: Spear in Ursella's side = Cerebroside sulfate is the accumulated substrate

Q: Clinical features of Metachromatic Leukodystrophy include:
1.) [movement]
2.) Central and peripheral demyelination
3.) Dementia
A: Ataxia
Extra: Flipper stuck to ocean floor = Ataxia

Q: Clinical features of Metachromatic Leukodystrophy include:
1.) Ataxia
2.) [Weakness due to]
3.) Dementia
A: Central and peripheral demyelination
Extra: Tentacles that resemble nerves = Central and peripheral demyelination

Q: Clinical features of Metachromatic Leukodystrophy include:
1.) Ataxia
2.) Central and peripheral demyelination
3.) [...]
A: Dementia
Extra: Stars spilling around head = Dementia